The introduction of new vaccines
Smallpox vaccination started in the early 19th century. It was over a hundred years before another vaccine was introduced for widespread use. This was diphtheria toxoid, that was used nationally from 1940. The dates of the introductions of the different vaccines into the routine UK childhood immunisation schedule are shown in the table below.
 
 
Disease               Routine vaccination started      Routine vaccination stopped
Smallpox                            Early 1800s                                    1971
Diphtheria                                1941
Tuberculosis (TB)                    1953                                          2005
Polio                                         1956
Pertussis (whooping cough)     1958
Tetanus                                    1961 (in new 3 in 1 DTP)
Measles                                    1968
Rubella (German measles)       1971 (for teenage girls only)
MMR                                         1988
Hib (Haemophilus Influenzae)  1992
MMR                                         1996 (2nd MMR at 4 years)
Men C (Meningitis C)                1999
Pneumococcus                         2006
 
The increasing vaccine burden
The number of vaccines routinely given to every child in the UK over the last hundred years is shown graphically below.
There have been calls over recent years to introduce several new vaccines to the UK childhood immunisation schedule. These include hepatitis B, flu, chickenpox, rotavirus and hepatitis A. All these vaccines are given routinely in the USA.
If they were all given to babies in the UK over the coming years, the number of vaccines received by five years of age may be as many as 43, as shown below.
A WHO doctor has already described the 21st century as the “Century of the Vaccines.”[1] There appears to be endless enthusiasm for introducing a seemingly unlimited number of vaccines. But there is no discussion on the maximum number of vaccines that a child should be given. Indeed most vaccine experts appear unconcerned about the possibility that we may, at some stage, be giving some children too many vaccines. Instead they talk about children being able to handle “thousands” of vaccines at any one time. [2] [3]
 
[1] de Quadros CA. Roadmap for vaccinations in the new millennium. Lancet 1999; 354: 2006-7.
[2]  Offit PA et al. Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system? Pediatrics 2002; 109(1): 124-9.
[3] Sir Liam Donaldson, Chief Medical Officer. February 2006.