Lance C. Bridges, Ph.D.
Assistant Professor of Chemistry
University of Central Arkansas
office: Laney Annex Rm 124
lab: Laney Hall Rm 300
ph: 501-852-2655
fax: 501-450-3623
Mailing: UCA, Dept of Chemistry
Laney Hall Rm 205
201 Donaghey Ave.
Conway, AR 72035
Education/Training:
B.S. Biochemistry, John Brown University, Siloam Springs, AR May 2000
Ph.D. University of Oklahoma Health Science Center, Department of Biochemistry &
Molecular Biology, Oklahoma City, OK December 2003
Mentor: Dr. Ron Bowditch
Thesis: Leukocyte Integrin Recognition of ADAM Family Members:
Delineation of Molecular Interactions of Homologous Mammalian Disintegrins.
Post-Doctoral Research Fellowship, University of Virginia, Department of Cell and
Developmental Biology, Charlottesville, VA 2004-2006
Project: ADAM Proteolytic and Adhesive Function in Cell Migration of Cranial
Neural Crest Cells During Early Murine and Xenopus Development
Publications:
1. Charles M. Roberts, Patricia H. Tani, Lance C. Bridges, Zoltan Laszik, and Ron D. Bowditch. (1999) MDC-L, a Novel Metalloprotease Disintegrin Cysteine-Rich Protein Family Member Expressed by Human Lymphocytes. J. Biol.
Chem. 274:29251-29259
2. Lance C. Bridges, Patricia H. Tani, Krista R. Hanson, Charles M. Roberts, Matthew B.Judkins, and Ron D. Bowditch. (2002). The Lymphocyte Metalloprotease MDC-L (ADAM28) is a Ligand for the Integrin alpha4beta1. J. Biol. Chem. 277:3784-3792
3. Lance C. Bridges, Krista R. Hanson, Patricia H. Tani, Timothy Mather, and Ron D. Bowditch. (2003) Integrin
alpha4beta1 Dependent Adhesion to ADAM28 (MDC-L) Requires an Extended Surface of the Disintegrin Domain.
Biochemistry 42:3734-3741
4. Lance C. Bridges, Dean Sheppard, and Ron D. Bowditch. (2005) ADAM Disintegrin-like Domain Recognition by the
Lymphocyte Integrins alpha4beta1 and alpha4beta7. Biochem. J. 387(1):101-108
5. Lance C. Bridges and Ron D. Bowditch. (2005) ADAM-Integrin Interactions; Potential Integrin Regulated Ectodomain
Shedding Activity. Curr. Pharm. Design 11(7):837-847
6. Judith M. White, Lance C. Bridges, Douglas W. DeSimone, Monika Tomczuk, Tyra G. Wolfsberg. (2005) Introduction to
the ADAM family. Proteases in Biology and Diseases, N.M. Hooper and U. Lendeckel, Editors. Springer. vol 4: pgs 1-28
7. Jing Huang, Lance C. Bridges, and Judith M. White. (2005) Selective Modulation of Integrin Mediated Cell Migration by Distinct ADAM Family Members. Molec. Biol. Cell 16(10):4982-4991
8. Lance C. Bridges, Joshuah D. Lingo, Rachel A. Grandon, and Melissa D. Kelley. All-trans-Retinoic Acid Induces Integrin-independent B-cell Adhesion to ADAM Disintegrin Domains. Biochemistry 47(15):4544-4551
