Youngest son of Indianapolis 500, Formula One and Champ Car Champion Mario Andretti. Jeff started racing go-karts- - like his brother Michael winning 21 of 43 events between 1981 and 1982. He took championships in the Yamaha 100cc heavy weight class and unlimited class.

In 1983, Jeff won both the USAC Pro Ford championship and the Skip Barber Formula ford Eastern Series title, earning Rookie of the Year honors in the latter series. Jeff qualified for his Sports Car Club of America national license in 1984 and was named SCCA Rookie of the year winning six of 13 races. Jeff also won the Northeast Division title in Formula Ford and made his Super VEE debut at Las Vegas in the last event of the season.

Jeff started on the pole and won the Super Vee race, and Mario did the same in the Champ Car event, marking the first time a father and son had started on the pole and won races on the same track in the same weekend.

Jeff advanced to the new American Racing Series in 1986, a series designed to be the primary stepping-stone to the PPG Champ Car World Series (now called Indy Lights). Jeff earned his first ARS win at Pocono, the same weekend his father finished first in the Champ Car race which his brother had started from the pole, giving the family a "clean sweep." Jeff clinched second place in the ARS point standing.

Jeff expanded his driving experience in the American Racing Series, as well as the Corvette Challenge Series and the GTP class of IMSA.

In 1989 Jeff competed in the Toyota Atlantic Series, taking on the difficult challenge of developing a new chassis and engine. He earned Rookie of the Year honors and had five to ten finishes, while taking second place in the Toyota Championship Points Fund - - Atlantic Division.

Jeff joined his father and brother in the Champ Car ranks in 1990, making racing history, marking the first time a father has competed against his two sons in a Champ Car race. Jeff made his series debut at Milwaukee, although mechanical problems led him to a 17th place finish.

In 1991, Jeff began his first full season in Champ Car competition, driving the Texaco Havoline Star for Bayside Motor Sports. With three top-ten finishes in the three races leading up to the prestigious Indy 500, Jeff gained the confidence and experience necessary to qualify 11th in the elite 33 car field.

His consistent performance during the month of May at Indianapolis, coupled with his outstanding drive in the race, earned him the 1991 Indy 500 Rookie of the Year honors. In winning the coveted award, Jeff followed in the footsteps of his father and brother making it the first time ever that three members of the same family have achieved this level of excellence. Jeff finished the season in similar fashion, also earning CART Rookie of the Year.

The 1992 season signaled Jeff's return to the Indianapolis 500, driving for legendary racer A.J. Foyt Jr's team. Jeff's on track diligence paid dividends as he qualified for the traditional race on the first day of time trials. He proved that he even learned a trick or two from the crafty veteran Foyt by qualifying three spots ahead of the four-time champion. Unfortunately, a spectacular crash ended Jeff's day on lap 109. After spending three weeks at Methodist Hospital in Indianapolis, Jeff began the long road to rehabilitation and recovery, determined to race again in 1993.

His comeback efforts completed, Jeff qualified in sixteenth position, driving for Pagan Racing, in the 1993 Indianapolis 500. His Memorial Day weekend concluded with a twenty-ninth place finish in the annual Brickyard classic. Also in that year he set a close course record at Texas World Speedway with a speed of 234.5 MPH.

In 1994 Jeff and his wife, Angelica, welcomed their first child, Miranda. The month of May brought Jeff back to Indianapolis and the 1994 Indy 500. Jeff's bid for a fourth consecutive start was halted by a blown engine on the last day of qualifying.

Andretti returned full-time to racing in 1995, driving for Canaska Racing with an impressive season in the Indy Lights series. For 1996 and 97, Jeff drove for Leitzinger Racing in the new, North American Touring Car Series.

In 1998 Jeff and his wife, Angelica, welcomed their second child, Isabella.

In 1999-2000 competed in the Nascar Craftman Truck Series and worked with an entertainment company putting marketing packages together for racing teams. For example: the entertainment company worked with Walker Motorsports with Champcar Series.

In 2001-2004 went to work for my brothers motorcycle company working in sales and then moved up into managing his online motorcycle accessory business and parted ways to pursue other stuff.  Also worked with my nephew with coaching him in his racing career in 2003 and we achieved a championship that year. Also in 2003 I started doing ride and drive programs with 2 different event companies. The company I work for first was ACMI, I did one of there event with the Mazda Rev it up program and then I work for Event Solutions Intl with there VW dealer launch program.  I once again work on another Event solutions program with once again VW with there VW Drivers Cup. Also working at my Dad’s racing school as a guest driver instructor. This is a part-time thing to fill in gaps in my schedule. 

In 2005 I worked for AMCI on 3 of there programs. First program is the AMG Challenge which I did the  whole  tour and the second one I am working part time on is the Chrysler Spring Training. The Third program is the GM summit tour which I am doing the whole tour. Fourth program was the Taste of Lexus Safety Seminar.

In 2006 I worked for AMCI again with the Cadillac Driving Center and Cadillac “V” Challenge.

In 2007 I worked for Event Solutions on the Ferrari Challenge as a driver coach. Did some Driver Coaching in the Indy Pro Series coaching Jonathan Klein & Stephen Simpson.  Also work with AMCI on there Toyota Tundra Program.

In 2008 i once again worked for AMCI on the AMG Challenge, Lexus Driving Academy & Toyota Tundra TDA .